Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

Figure 1

Increased mortality, but no difference in degree of diastolic HF in TLR9-deficient SERCA2A KO mice. (a) Survival analysis: median 58 days in TLR9-deficient SERCA2a KO mice versus 63 days in SERCA2a KO mice. The groups were compared using log rank (Mantel-Cox test: WT, ; TLR9 KO, ; SERCA2a KO, ; and SERCA2a/TLR9 KO, ). Of the 52 animals in the survival study, 16 animals were euthanized due to severe illness and 26 died spontaneously. (b) LV inner diastolic diameter/TL (LVID;d, mm). (c) LV inner systolic diameter/TL (LVID;s, mm). (d) Left atrium/TL (mm). (e) Relative wall thickness (RWT). TL, tibia length (mm). The groups were compared using two-way ANOVA with Tukey’s multiple comparison test post hoc. Data are shown as mean ± SEM. , , and versus corresponding control.

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