Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

Figure 2

Quantitative RT-PCR on LV myocardial tissue from mice with HF 7.6 weeks after SERCA2a gene excision. (a) ANP, atrial natriuretic peptide, (b) BNP, brain natriuretic peptide, (c) βMHC, beta myosin heavy chain, and (d) αSMA, alpha smooth muscle actin. The groups (WT, ; TLR9 KO, ; SERCA2a KO, ; and SERCA2a/TLR9 KO, ) were compared using two-way ANOVA with Tukey’s multiple comparison test post hoc. Data are shown as mean ± SEM. , versus corresponding control.

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