Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

Table 1

Echocardiographic parameters in SERCA2a KO, SERCA2a/TLR9 KO, and control mice 7.6 weeks after gene excision.

	Controls		HF
	WT ()	TLR9 KO ()	SERCA2a KO ()	SERCA2a/TLR9 KO ()
LVEF (%)	39.0 ± 5.1	44.9 ± 5.6	42.2 ± 2.6	45.2 ± 4.2
SV (μl)/TL	1.5 ± 0.2	1.7 ± 0.2	1.2 ± 0.1	1.2 ± 0.1
IVS;d (mm)/TL	0.04 ± 0.002	0.03 ± 0.002	0.04 ± 0.002	0.04 ± 0.002
IVS;s (mm)/TL	0.06 ± 0.002	0.04 ± 0.004	0.05 ± 0.002	0.04 ± 0.003
LVPW;d (mm)/TL	0.05 ± 0.004	0.05 ± 0.006	0.05 ± 0.002	0.05 ± 0.003
LVPW;s (mm)/TL	0.05 ± 0.004	0.06 ± 0.01	0.06 ± 0.003	0.06 ± 0.004
LVvol;d (μl)/TL	3.7 ± 0.3	3.8 ± 0.4	2.9 ± 0.2	2.6 ± 0.2
LVvol;s (μl)/TL	2.3 ± 0.3	2.2 ± 0.4	1.7 ± 0.2	1.5 ± 0.2

LV: left ventricle; EF: ejection fraction; SV: stroke volume; d: diastolic; s: systolic; IVS: interventricular septum thickness; LVPW: LV posterior wall thickness; LVvol: LV volume; TL: tibia length (mm). The groups were compared using two-way ANOVA with Tukey’s multiple comparison test post hoc. Data are mean ± SEM. versus corresponding TLR9 KO control.