MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats

Figure 4

Effect of miR-146a on NF-κB expression in the iris and ciliary body by immunofluorescence. NF-κB expression was not observed in the control group. NF-κB was profoundly expressed in the MAA and MAA + negative mimic groups. Following miR-146a treatment, reduction of NF-κB expression in a dose-dependent manner was noted. The slices counterstained with DAPI were consistent with these results. Ctrl = control; MAA = melanin-associated antigen; miR-146a L = low-dose miR-146a; miR-146 H = high-dose miR146a; DAPI = 4′,6-diamidino-2-phenylindole.