(a)
(b)
Figure 1: Structure of TLR4/MD-2 ectodomains, in a heterotetrameric form, as seen from (a) or (b). The TLR4 molecule (green) is constitutively bound to MD-2 (magenta), and the TLR4 (cyan) molecule is constitutively bound to MD-2 (yellow). Dimerisation interfaces form between TLR4 and MD-2 and vice versa. Images were created by adapting the structure of TLR4 (PDB code: 3FXI) using PyMOL [37].