Protease Domain Cell type Substrate or interaction partner Process Reference ADAM8 D TNBC, pancreatic cancer Invasion, metastasis [48 , 183 ] ADAM8 ? Glioma cells ? invasion [184 ] L-ADAM9 D Breast cancer ? Inhibition of migration [185 ] S-ADAM9 MP Breast cancer ? migration [185 ] ADAM9 MP Pancreatic cancer cells, esophageal squamous cell carcinoma E-cadherin Invasion, metastasis [186 ] D, CR Melanoma cells Cell-cell interaction and ECM degrading capacity, invasion [142 ] D Prostate cancer Inhibition of migration and invasion [187 ] D, CR Colon carcinoma, hepatic stellate and breast cancer cells Liver metastasis [188 ] ADAM10 MP Pituitary adenocarcinoma, glioblastoma, tumor cells in general CD44 Cell-contact inhibition, metastasis [93 , 189 , 190 ] MP Ovarian cancer cells, prostate cancer cells CXCL16, Migration, metastasis, attraction of cancer cells [191 –193 ] MP Esophageal squamous cell carcinoma, breast cancer, pancreatic cancer E-cadherin, cadherin-catenin-interaction Cell-cell contact, invasion, migration [194 , 195 ] MP Pituitary adenocarcinoma, glioma L1CAM Migration [149 , 196 –198 ] MP glioblastoma N-cadherin, cytoskeletal rearrangement, RAGE Migration [82 , 199 ] MP Melanoma, gastric cancer cells, non-small-cell lung cancer Notch1 Migration and invasion [200 –202 ] Hepatocellular carcinoma PI3K/AKT activation Invasion [203 ] ? Gliobastoma sphere-forming cells Inhibition metastasis [204 ] D Oral squamous cell carcinoma Migration and invasion [205 ] ADAM12 ? Breast cancer cells ? Invasion, metastasis [206 ] D, CR Melanoma cells Migration [207 ] MP Lung tumor cells Ephrin A1 Extravasation [208 ] ADAM15 MP Breast cancer cells E-cadherin Migration [209 ] MP Non-small lung cancer Pro-MMP9 Migration (ECM degradation) [210 ] MP Breast cancer cells HB-EGF Migration [211 ] D Ovarian cancer cells Decrease of migration [212 ] MP Prostate cancer cells ? Block of extravasation and bone metastasis [209 ] ADAM17 MP Ovarian carcinoma, thyroid tumors ALCAM Invasion (loss of adhesion), metastasis [213 ] MP Adenoma cells CD44 Invasion (loss of adhesion) [93 ] MP Breast cancer, glioblastoma EGFR ligands Invasion [214 –217 ] MP Nasopharyngeal carcinoma EGFR ligands, E-cadherin Migration, invasion [218 ] MP Gastric cancer cells, liver cancer Notch1 Migration [201 ] ADAM17 MP Colon carcinoma PTK7 Migration [219 ] MP Lung cancer cells Syndecan-1 Metastasis, invasion [174 , 175 ] ? Gliobastoma sphere-forming cells Inhibition metastasis [204 ] ADAM19 MP Retinoblastoma cells, non-small-cell lung cancer, glioma ? Invasion, metastasis [184 ] ADAM23 MP Breast cancer Metastasis [220 ]
