Mediators of Inflammation

Review Article

Macrophages as Key Drivers of Cancer Progression and Metastasis

Table 1

Markers used to identify murine macrophage populations in healthy and tumour-bearing mice.


Type	Population	Markers	Reference

Healthy tissues	Microglia (During embryonic development)	CD11b⁺ CX3C1⁺ F4/80⁺ CSF1R⁺ Gr1⁻ F4/80⁺	Ginhoux et al., Science [11]
	Alveolar macrophages (Adult)	CD11b⁺ F4/80⁺ CD64⁺	Guilliams et al., JEM [12]
	Colon macrophages
	Embryonic	CD45⁺ Siglec-F⁻ Ly6G⁻ CD64+	Bain et al., Nature Immunology [15]
	Adult	CD45⁺ Siglec-F⁻ Ly6G⁻ CD64+ CD11b⁺	Bain et al., Nature Immunology [15]

Blood-derived cells in adult mice	Patrolling monocytes	CCR2^- CD62L^-	Auffray et al., Science [19]
	Inflammatory monocytes	CCR2⁺ CD62L⁺	Auffray et al., Science [19]
	Neutrophils	CD45⁺ CD11b⁺ F4/80⁻ Ly6C⁺	DeNardo et al., Cancer Disc. [24]

Tumour associated macrophages (TAM)	Breast cancer (MMTV-PyMT Model)
	TAMs	CCR2⁺ F4/80⁺ CD64⁺ MerTK⁺	Franklin et al., Science [31]
	Mammary-resident macrophages		Franklin et al., Science [31]
	Breast cancer (MMTV-PyMT Model)
	TAMs	CD11b⁺ Gr1⁻ F4/80⁺	DeNardo et al., Cancer Cell [37]
		CD45⁺ CD11b⁺ Ly6G⁻ F4/80⁺	DeNardo et al., Cancer Disc. [24]
		CD11b⁺ F4/80⁺ MHCII⁺ Ly6C⁻	Ruffell et al., Cancer Cell [57]
	Breast cancer
	Subcutaneous N202 mammary tumors
	Tie2-expressing monocytes (TEM)	CD45⁺ CD11b⁺ F4/80⁺ Tie2⁺ CD31⁻	DePalma et al., Cancer Cell [103]
	TAMs	CD45⁺ CD11b⁺ F4/80⁺ Tie2⁻ CD31⁻	Pucci et al., Blood [104]
	Pancreatic cancer
	TAMs (Orthotopic KPC)	CD11b+ F4/80+ Gr1- MHCII⁺	Zhu et al., Cancer Research [28]
	TAMs (KC model; p48-CRE/LSL-KRas)	CD11b+ Gr1-	Clark et al., Cancer Research [105]
	Glioma (PDGF-B–driven glioma)
	TAMs	CD45⁺ CD11b⁺ CD68⁺ CSF1R⁺ Gr1⁻	Pyonteck et al., Nat Med [91]