Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation

Figure 4

MEDI3622 binds to the unique loop in the ADAM17 structure. (a) Modeling of binding of MEDI3622 to ADAM17. sIVa-sIVb loop is shown in cyan. (b) Overlay of ADAM17 (magenta), ADAMTS-5 (blue), MMP-9 (cyan), and ADAM22 (gray) structures shows that the sIVa-sIVb loop does not align with structures of other metzincins suggesting its uniqueness. Adopted with permission from [154].

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