Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Table 4

Association of TNF-308, IL17A, and IL17F with the risk of AS, stratified by gender and HLA-B27 marker.

Gene (SNP)	Allele genotypes	AS () [n (%)]	Controls () [n (%)]	value^1	OR (95% CI)
TNF-308 (rs1800629)	G/G	95 (55.2)	150 (71.4)
	G/A	74 (43.0)	58 (27.6)
	A/A	3 (1.7)	2 (1.0)
	G/A + A/A	77 (44.8)	60 (28.6)	0.004	1.9 (1.2–3.0)
		()	()
IL17A (rs2275913)	G/G	81 (47.1)	123 (58.6)
	G/A	74 (43.0)	71 (33.8)
	A/A	17 (9.9)	16 (7.6)
	G/A + A/A	91 (52.9)	87 (41.4)	0.01	1.7 (1.1–2.6)
		()	()
IL17F (rs763780)	T/T	119 (66.6)	188 (90.0)
	T/C	48 (28.1)	20 (9.6)
	C/C	4 (2.3)	1 (0.5)
	T/C + C/C	52 (30.4)	21 (10.1)	<0.001	3.7 (2.1–6.6)

SNP: single-nucleotide polymorphism; AS: ankylosing spondylitis; OR: odds ratio; CI: confidence interval. ¹Statistical analysis was performed by SNPStats software based on a statistical dominant model.