Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Table 5

Association of TNF-238, IL17A, and IL17F with the risk of PsA, stratified by gender and HLA-B27 marker.

Gene (SNP)	Allele genotypes	PsA () [n (%)]	Controls () [n (%)]	value^1	OR (95% CI)
TNF-238 (rs361525)	G/G	50 (74.6)	181 (86.2)
	G/A	16 (23.9)	28 (13.3)
	A/A	1 (1.5)	1 (0.5)
	G/A + A/A	17 (25.4)	29 (13.8)	0.02	2.3 (1.1–4.5)
		()	()
IL17A (rs2275913)	G/G	30 (44.8)	123 (58.6)
	G/A	27 (40.3)	71 (33.8)
	A/A	10 (14.9)	16 (7.6)
	G/A + A/A	37 (55.2)	87 (41.4)	0.02	1.9 (1.1–3.4)
		()	()
IL17F (rs763780)	T/T	40 (59.7)	188 (90.0)
	T/C	26 (38.8)	20 (9.6)
	C/C	1 (1.5)	1 (0.5)
	T/C + C/C	27 (40.3)	21 (10.1)	<0.001	6.6 (3.3–13.1)

SNP: single-nucleotide polymorphism; PsA: psoriatic arthritis; OR: odds ratio; CI: confidence interval. ¹Statistical analysis was performed by SNPStats software based on a statistical dominant model.