Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Table 6

Distribution of TNF-308/IL17A/IL17F haplotypes in individuals with SpA, AS, and PsA (interaction analysis with gender covariate).

Haplotype	SpA	AS	PsA
TNF-308/IL17A/IL17F	OR (CI 95%)	OR (CI 95%)	OR (CI 95%)
GGC	3.9 (1.7–9.0)	2.5 (1.1–5.7)	7.0 (2.8–17.7)
GAC	5.0 (2.1–12.0)	4.1 (1.6–10.3)	5.5 (1.4–22.1)
AAT	4.2 (1.6–11.3)	4.4 (1.5–13.1)	5.2 (1.1–23.7)

SpA: spondyloarthritis; AS: ankylosing spondylitis; PsA: psoriatic arthritis; OR: odds ratio; CI: confidence interval.