New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation

Figure 3

Role of the citrate pathway in Behçet’s syndrome (BS). In BS cells, different triggers induce an increase of the SLC25A1 and ACLY transcription rate. The citrate carrier (CIC)—SLC25A1 encoded protein—exports citrate from mitochondria to the cytosol where it is cleaved by ACLY into oxaloacetate and acetyl-CoA. Both the metabolites support the production of the inflammatory mediators.