Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

Table 1

The negative regulation factors of inflammasomes.

Regulation of factors	Target	Mechanism
A20/TNFAIP3 [34]	NLRP1	Binding with Bcl-2 and Bcl-X(L)
miR-223 [38]	NLRP3	Acting on a conserved binding site within 3 untranslated region of NLRP3
miR-7 [39]	NLRP3	Posttranscriptionally controlled NLRP3 expression
Human CD4^+ memory T cells [41]	NLRP3	Down-regulation of P2X7R signaling molecules
Caspase-12 [42]	Caspase-1	Associated with caspase-1
POM-1 [43]	NLRP1	Inhibit the events related with ATP-dependent inflammasome
Probenecid [44]	NLRP3	Block pannexin 1 channel and high extracellular potassium
Type I interferons [86]	NLRP1/NLRP3	Via the STAT1 transcription factor

A20/TNFAIP3: tumor necrosis factor α-induced protein 3; NLRP1/NLRP3: NOD-like receptors pyrin domain-containing 1 or 3; POM-1: polyoxotungstate-1.