Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study

Table 1

Biochemical, clinical, demographic, lifestyle, and tomography characteristics of the study population.

	Control ()	Premature CAD ()	value
Demographic
Age (years)	51 ± 9	54 ± 8	<0.001
Gender (% male)	41.1	81.0	<0.001
Biochemical and clinical characteristics
Body mass index (kg/m^2)	27.9 [25.4-30.8]	28.3 [25.9-31.1]	0.004
Systolic blood pressure (mmHg)	112 [104-122]	116 [106-127]	<0.001
Diastolic blood pressure (mmHg)	71 [65-76]	71 [66-78]	0.011
Total cholesterol (mg/dL)	189 [166-210]	160 [132-193]	<0.001
High density lipoprotein cholesterol (mg/dL)	45 [36-55]	37 [32-44]	<0.001
Low density lipoprotein cholesterol (mg/dL)	115 [95-134]	91 [69-116]	<0.001
Triglycerides (mg/dL)	145 [107-201]	162 [119-219]	<0.001
Aspartate aminotransaminase (IU/L)	25 [21-30]	26 [22-31]	0.001
Gamma-glutamyltransferase (IU/L)	26 [18-42]	33 [22-49]	<0.001
Adiponectin (μg/mL)	8.1 [5.0-12.8]	5.2 [3.2-8.1]	<0.001
Total (%)	36.6	30.2	<0.001
Hypo-α-lipoproteinemia (%)	52.0	67.2	<0.001
LDL pattern B (%)	47.0	62.0	<0.001
Low adiponectin (%)	42.8	57.5	<0.001
Hypertension (%)	18.9	68.0	<0.001
Type 2 diabetes mellitus (%)	9.8	35.6	<0.001
Increased aspartate aminotransaminase activity (%)	36.3	38.9	0.207
Increased gamma-glutamyltransferase activity (%)	41.3	49.9	<0.001
Tomography
Total abdominal fat (cm^2)	432 [347-534]	425 [339-523]	0.254
Visceral abdominal tissue (cm^2)	139 [104-180]	168 [129-215]	<0.001
Subcutaneous abdominal fat (cm^2)	286 [218-366]	245 [193-313]	<0.001
Lifestyle
Current smoking (%)	22.8	11.7	<0.001

Data are shown as deviation, median [interquartile range], or percentage. Student test, Mann-Whitney test or chi-square test. CAD = coronary artery disease; HDL = high-density lipoprotein; LDL = low-density lipoprotein.