Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study
Table 2
Association of Raet1e gene polymorphisms with premature coronary artery disease.
Polymorphism
(genotype frequency)
MAF
Model
OR [95% CI]
rs6925151
C > T
CC
CT
TT
Control ()
392 (0.355)
510 (0.462)
202 (0.183)
0.414
Heterozygote
1.250 [1.027-1.521]
0.026
CAD ()
373 (0.322)
569 (0.491)
216 (0.187)
0.432
Codominant 1
1.268 [1.018-1.581]
0.034
rs9371533
A > G
AA
AG
GG
Control ()
293 (0.265)
523 (0.474)
288 (0.261)
0.498
Heterozygote
1.255 [1.031-1.527]
0.024
CAD ()
314 (0.271)
585 (0.505)
259 (0.224)
0.476
rs7756850
G > C
GG
GC
CC
Control ()
316 (0.285)
523 (0.474)
265 (0.240)
0.477
Heterozygote
1.274 [1.047-1.550]
0.016
CAD ()
299 (0.258)
584 (0.504)
275 (0.237)
0.490
Codominant 1
1.294 [1.024-1.635]
0.031
rs9383921
C > T
CC
CT
TT
Control ()
318 (0.288)
525 (0.476)
261 (0.236)
0.474
Heterozygote
1.232 [1.012-1.499]
0.037
CAD ()
318 (0.261)
584 (0.504)
272 (0.235)
0.487
Data are expressed as odds ratio (OR) and 95% confidence interval (CI) as assessed by multivariate logistic regression analysis. Each model was adjusted for age, gender, body mass index, current smoking, and type 2 diabetes mellitus. MAF = minor allele frequency.
