Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study
Table 4
Association of raet1e gene polymorphisms with clinical and metabolic parameters in the control group.
Polymorphism
(genotype frequency)
MAF
Model
OR [95% CI]
Controls
Hipo-α-lipoproteinemia
rs9371533
AA
AG
GG
No ()
125 (0.236)
277 (0.522)
128 (0.242)
0.503
Heterozygote
0.694 [0.545-0.885]
0.003
Yes ()
168 (0.293)
246 (0.429)
160 (0.279)
0.493
Codominant 1
0.658 [0.490-0.884]
0.005
LDL pattern B
rs566850
CC
CG
GG
No ()
153 (0.262)
277 (0.473)
154 (0.265)
0.502
Additive
0.815 [0.690-0.964]
0.017
Yes ()
164 (0.316)
245 (0.473)
110 (0.211)
0.448
rs9383921
CC
CT
TT
No ()
158 (0.270)
273 (0.466)
154 (0.263)
0.496
Recessive
0.710 [0.533-0.946]
0.019
Yes ()
161 (0.310)
251 (0.484)
107 (0.206)
0.409
AST > p75
rs7756850
CC
CG
GG
No ()
184 (0.261)
343 (0.486)
178 (0.253)
0.496
Dominant
0.720 [0.549-0.944]
0.018
Yes ()
133 (0.333)
179 (0.446)
88 (0.221)
0.387
rs9383921
CC
CT
TT
No ()
183 (0.260)
345 (0.489)
177 (0.251)
0.496
Additive
0.800 [0.673-0.951]
0.011
Yes ()
136 (0.341)
178 (0.446)
85 (80.213)
0.436
Dominant
0.695 [0.695-0.911]
0.008
Codominant 2
0.651 [0.461-0.919]
0.015
Data are expressed as odds ratio (OR) and 95% confidence interval (CI) as assessed by multivariate logistic regression analyses. All models were adjusted by age, gender, and body mass index. MAF = minor allele frequency; AST = aspartate aminotransaminase.
