Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?
Table 1
Characteristics of subjects in terms of the level of serum TPOAb and TgAb.
Total
TPO and TgAb (−)
TPO/TgAb (+)
value
Men
(%)
3948 (100)
3548 (89.9)
400 (10.1)
—
Age (year)
53.93 ± 13.12
53.91 ± 13.05
54.13 ± 13.82
0.753
Smokers (%)
55.3
55.8
51.3
0.095
Systolic BP (mmHg)
134.31 ± 20.66
134.41 ± 20.80
133.42 ± 19.45
0.347
BMI (kg/m2)
24.82 ± 3.35
24.80 ± 3.35
25.04 ± 3.36
0.174
WC (cm)
84.23 ± 9.60
84.22 ± 9.60
84.37 ± 9.55
0.777
FPG (mmol/L)
5.70 ± 1.52
5.72 ± 1.56
5.55 ± 1.15
0.481
HOMA-IR
1.47 ± 2.21
1.48 ± 2.30
1.32 ± 1.15
0.461
HbA1c (%)
5.61 ± 1.01
5.62 ± 1.02
5.52 ± 0.91
0.112
LDL (mmol/L)
3.07 ± 0.76
3.07 ± 0.77
3.06 ± 0.69
0.807
HDL (mmol/L)
1.36 ± 0.32
1.36 ± 0.32
1.35 ± 0.30
0.557
TG (mmol/L)
1.88 ± 1.95
1.90 ± 2.02
1.74 ± 1.19
0.856
TC (mmol/L)
5.15 ± 1.13
5.16 ± 1.14
5.11 ± 1.00
0.400
TSH (mIU/L)
2.13 ± 0.92
2.11 ± 0.91
2.36 ± 0.99
<0.001
T3 (nmol/L)
1.79 ± 0.53
1.77 ± 0.42
1.94 ± 1.10
0.152
T4 (nmol/L)
113.87 ± 22.34
113.64 ± 22.42
116.00 ± 21.43
0.047
Hyperlipidemia (%)
42.2
42.2
42.3
0.972
Diabetes (%)
14.9
15.1
13.5
0.392
Hypertension (%)
51.3
51.7
48.2
0.193
Metabolic syndrome (%)
20.3
20.4
19.3
0.604
Cardiovascular events (%)
7.4
7.1
10.3
0.021
Women
(%)
5134 (100)
4077 (79.4)
1057 (20.6)
—
Age (year)
52.62 ± 13.11
52.56 ± 13.20
52.83 ± 12.77
0.562
Smokers (%)
2.8
3.0
1.8
0.036
Systolic BP (mmHg)
130.19 ± 22.28
129.99 ± 22.06
130.97 ± 23.11
0.207
BMI (kg/m2)
24.21 ± 3.60
24.13 ± 3.56
24.54 ± 3.74
0.002
WC (cm)
77.71 ± 9.99
77.54 ± 10.00
78.38 ± 9.92
0.017
FPG (mmol/L)
5.56 ± 1.34
5.56 ± 1.32
5.57 ± 1.42
0.623
HOMA-IR
1.56 ± 1.95
1.53 ± 1.77
1.67 ± 2.54
0.017
HbA1c (%)
5.45 ± 0.90
5.43 ± 0.88
5.52 ± 0.96
0.001
LDL (mmol/L)
3.06 ± 0.79
3.05 ± 0.79
3.10 ± 0.81
0.096
HDL (mmol/L)
1.48 ± 0.31
1.48 ± 0.32
1.47 ± 0.31
0.313
TG (mmol/L)
1.48 ± 1.14
1.46 ± 1.04
1.58 ± 1.47
0.003
TC (mmol/L)
5.14 ± 1.13
5.15 ± 1.16
5.15 ± 1.03
0.994
TSH (mIU/L)
2.46 ± 1.00
2.42 ± 1.00
2.59 ± 1.02
<0.001
T3 (nmol/L)
1.73 ± 0.40
1.72 ± 0.36
1.77 ± 0.50
0.018
T4 (nmol/L)
115.49 ± 19.59
115.17 ± 19.20
116.73 ± 20.99
0.029
Hyperlipidemia (%)
31.3
30.4
34.7
0.006
Diabetes (%)
12.0
11.7
13.1
0.230
Hypertension (%)
41.1
40.8
42.1
0.449
Metabolic syndrome (%)
26.5
25.6
29.8
0.007
Cardiovascular events (%)
7.5
7.3
8.5
0.168
value: TPO/TgAb (+) versus TPO and TgAb (−). Data are presented as the mean ± standard deviation for continuous variables or as a percentage (%) for categorical variables. BP, blood pressure; BMI, body mass index; WC, waist circumference; FPG, fasting blood glucose; HOMA-IR, homeostasis model assessment of insulin resistance; HbA1c, glycated hemoglobin; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; TC, total cholesterol; TSH, thyroid-stimulating hormone; T3, triiodothyronine; T4, thyroxin.
