Salivary Gland Extract of Kissing Bug, Triatoma lecticularia, Reduces the Severity of Intestinal Inflammation through the Modulation of the Local IL-6/IL-10 Axis

Figure 2

T. lecticularia SGE improves intestinal shortening in mice exposed to DSS. Intestinal inflammation was induced by free consumption of drinking water containing 3% DSS for 6 consecutive days. Mice were treated i.p. with 100 μl of saline or T. lecticularia SGE (3, 10, or 30 μg/animal/day). Dashed lines: healthy mice without treatment and not exposed to DSS (control); dotted lines: healthy mice not exposed to DSS and treated with T. lecticularia SGE (30 μg). The NO production (a) was assessed as described in Methods. Results were normalized to the dry weight of each intestinal section and expressed as micrograms per milliliter per gram of tissue (μg/ml/g). The intestinal length (b, c) was recorded at the day of euthanasia. Results are representative of two independent experiments ( mice/group). .

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