A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis

Figure 3

Measured BChE enzyme activity predicts the patient outcome following sepsis. (a) Kaplan–Meier curve shows the survival analysis of septic patients included in this study. (b) ROC curve analysis for the BChE activity measured at the time point of the clinical detection of sepsis revealed an AUC of 0.7 with the optimal cutoff value of 1.661 × 10³ U/L (CI 0.5–0.8, 94% sensitivity, 48% specificity). (c) A comparison of the Kaplan–Meier curves stratified according to the cutoff value for the measured BChE enzyme activity, as shown in (b). BChE: butyrylcholinesterase; ROC: receiver operating characteristic; AUC: area under the curve; CI: confidence interval; c.o.v.: cutoff value.

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