A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis

Figure 4

Disease severity scores predict outcome in patients with sepsis. APACHE II (a, b), SOFA (c, d), and SAPS II (e, f) scores were calculated from patients surviving sepsis (open circles) and from those who did not survive 90 days following sepsis detection (closed circles). Disease severity scores were obtained at the time point of the sepsis diagnosis and repeated 1, 2, 7, 14, 21, and 28 days later. Magnified time lines (b, d, f) show the disease severity scores obtained within the first two days following sepsis detection. Dark gray-shaded areas indicate the time points where the statistical significance could be observed ( for APACHE II, for SOFA, and for SAPS II; Mann–Whitney U test). Data points are medians. APACHE II: Acute Physiology and Chronic Health; SOFA: Sequential Organ Failure Assessment; SAPS II: Simplified Acute Physiology Score.