Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease

Figure 2

Diminished sRAGE pools are characteristic of individuals with concurrent AD and obesity. Participants were grouped by obesity status (lean: <25 kg/m², overweight: 25–29 kg/m², obese: ≥30 kg/m²), and sRAGE isoforms were measured in pg/mL as mentioned previously. Data are presented as mean ± SEM. Sample sizes for the stratifications are as follows: lean, NC (), lean, AD (), overweight, NC (), overweight, AD (), obese, NC (), and obese, AD (). value < 0.05 across metabolic factor within NC group; value < 0.05 across metabolic factor within AD group; value < 0.01 across groups within metabolic factor.

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