Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease

Figure 6

Aberrant cRAGE : esRAGE in individuals with high amylin and comorbid AD. Serum amylin was measured in pM following an overnight fast, and participants were stratified by the calculated median (6.8 pM). Data are presented as mean ± SEM. Sample sizes for the stratifications are as follows: low HOMA-IR, NC (), low HOMA-IR, AD (), high HOMA-IR, NC (), and high HOMA-IR, AD (). value < 0.01 across metabolic factor within AD group; value < 0.01 across groups within metabolic factor.

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