Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease

Table 1

Subject characteristics.

Variable (units)	NC ()	AD ()
Sex (number, % males)	26, 38%	36, 54%
Age (y)	73 ± 1	75 ± 1
BMI (kg/m^2)	29.5 ± 0.5	27.3 ± 0.8
Lean body mass (kg)	46 ± 1	46 ± 1
Fat mass (kg)	32 ± 1	27 ± 1
Type 2 diabetes (number, %)	22, 32%	19, 28%
HOMA-IR (AU)	2.4 ± 0.3	2.2 ± 0.2
Fasting glucose (mg/dL)	104 ± 3	101 ± 2
Fasting glucose (mmol/L)	5.8 ± 0.2	5.6 ± 0.1
Fasting insulin (mU/L)	9.1 ± 1.0	8.8 ± 0.8
Fasting amylin (pM)	11.2 ± 1.7	17.9 ± 5.3
S100B (pg/mL)	13.0 ± 1.7	14.4 ± 2.8

Data are presented as mean ± SEM. BMI: body mass index; HOMA-IR: homeostatic model assessment of insulin resistance. .