MicroRNA Expression Profile of Whole Blood Is Altered in Adenovirus-Infected Pneumonia Children

Figure 3

Quantification of miRNA expression levels by qRT-PCR. (a) Quantification of top 20 differently expressed miRNAs, including upregulated and downregulated miRNAs. Five samples from Adv-infected children and 5 from healthy controls were used in the experiment. (b) Quantification of top 5 upregulated miRNAs. 15 samples from Adv-infected children and 15 from healthy controls were used in the experiment. (c) The effect of miRNA inhibitors on the replication of Adv. After transfection with miRNA inhibitors, cells were infected with HAdV5 at an MOI of 10. Virus was harvested, and the titer was determined on 293T cells at the indicated time points. Data are shown as from three independent experiments. and (Student test).

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