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Mediators of Inflammation
Volume 2018, Article ID 2503950, 17 pages
https://doi.org/10.1155/2018/2503950
Review Article

Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair

Laboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas, Limeira, SP, Brazil

Correspondence should be addressed to Hosana G. Rodrigues; rb.pmacinu.acf@seugirdor.anasoh

Received 4 December 2017; Accepted 8 March 2018; Published 12 April 2018

Academic Editor: Naïma Moustaïd-Moussa

Copyright © 2018 Jéssica R. Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Wound healing is an evolutionarily conserved process that is essential for species survival. Wound healing involves a series of biochemical and cellular events that are tightly controlled, divided into 3 concomitant and overlapping phases: inflammation, proliferation, and remodelling. Poor wound healing or a chronic wound represents a silent epidemic that affects billions of people worldwide. Considering the involvement of immune cells in its resolution, recent studies are focused on investigating the roles of immune nutrients such as amino acids, minerals, and fatty acids on wound healing. Among the fatty acids, much attention has been given to omega-6 (ω-6) fatty acids since they can modulate cell migration and proliferation, phagocytic capacity, and production of inflammatory mediators. The present review summarizes current knowledge about the role of ω-6 fatty acids in the wound healing context.