A Snake Venom-Secreted Phospholipase A₂ Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis

Figure 2

MT-III induces upregulation of PPAR-γ and PPAR-β/δ protein expression in macrophages. Peritoneal macrophages were incubated with MT-III (0.4 μM) or RPMI (control) for 1, 6, 12, and 24 h. (a, b) Western blotting and densitometric analysis of the band intensities of immunoreactive PPAR-γ (a) or PPAR-β/δ (b) and β-actin (loading control) in macrophage extracts. Results are expressed as mean ± SEM from three experiments. compared with controls.

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(b)