Huanglian-Wendan Decoction Inhibits NF-κB/NLRP3 Inflammasome Activation in Liver and Brain of Rats Exposed to Chronic Unpredictable Mild Stress

Table 2

Identification of the compounds in water extract of Huanglian-Wendan decoction by LC–MS/MS analysis in positive ion mode.

Number	Retention time (min)	Adduct	Extraction mass (Da)	Found mass (Da)	Error (ppm)	Formula	Identification	Reference
1	4.49	+H	265.15467	265.15442	−0.9	C14H20N2O3	Subaphyllin	MassBank ID MSJ00004
2	6.58	+	342.16998	342.1702	0.6	C20H24NO4	Magnoflorine	[27]
3	8.69	+H	195.06519	195.06506	−0.7	C10H10O4	Ferulic acid	METLIN ID 4156
4	9.04	+	322.10738	322.10716	−0.7	C19H16NO4	Berberrubine	METLIN ID 86846
5	9.05	+H	597.1814	597.18134	−0.1	C27H32O15	Eriocitrin	METLIN ID 52850
6	9.12	+H	257.08084	257.08056	−1.1	C15H12O4	Liquiritigenin	[28]
7	9.42	+H	289.07066	289.07073	0.2	C15H12O6	Eriodictyol	METLIN ID 3415
8	9.42	+H	597.1814	597.18134	−0.1	C27H32O15	Neoeriocitrin	METLIN ID 52843
9	10.08	+	320.09173	320.09193	0.6	C19H14NO4	Coptisine	[27]
10	10.11	+H	581.18648	581.18619	−0.5	C27H32O14	Narirutin	METLIN ID 52724
11	10.16	+	336.12303	336.12287	−0.5	C20H18NO4	Epiberberine	[27]
12	10.28	+	338.13868	338.13842	−0.8	C20H20NO4	Jatrorrhizine	[27]
13	10.47	+H	273.07575	273.07598	0.8	C15H12O5	Naringenin	METLIN ID 3401
14	10.48	+H	581.18648	581.18619	−0.5	C27H32O14	Naringin	MassBank ID PB005724
15	10.59	+H	579.17083	579.17039	−0.8	C27H30O14	Rhoifolin	METLIN ID 44401
16	10.81	+H	611.19705	611.19675	−0.5	C28H34O15	Hesperidin	METLIN ID 3678
17	11.09	+H	609.1814	609.18146	0.1	C28H32O15	Diosmetin 7-neohesperidoside	METLINID 49249
18	11.17	+H	303.08631	303.08609	−0.8	C16H14O6	Hesperetin	METLIN ID 44508
19	11.17	+H	611.19705	611.19675	−0.5	C28H34O15	Neohesperidin	METLIN ID 3679
20	11.29	+	336.12303	336.12287	−0.5	C20H18NO4	Berberine	Mass Bank ID KO002476
21	11.44	+	352.15433	352.15407	−0.8	C21H22NO4	Palmatine	METLIN ID 6992
22	11.85	+H	419.13366	419.13363	−0.1	C21H22O9	Liquiritin	MassBank ID BML01654
23	12.27	+H	257.08084	257.08056	−1.1	C15H12O4	Isoliquiritigenin	[28]
24	13.21	+H	595.20213	595.20216	0	C28H34O14	Poncirin	MassBank ID PR100363
25	15.04	+H	331.08123	331.08133	0.3	C17H14O7	Tricin	MassBank ID FIO00740
26	16.48	+H	269.08084	269.08099	0.6	C16H12O4	Formononetin	METLIN ID 43917
27	17.60	+H	471.20134	471.20149	0.3	C26H30O8	Limonin	METLIN ID 44458
28	18.19	+H	471.34689	471.34677	−0.2	C30H46O4	Glycyrrhetinic acid	MassBank ID KO003037
29	18.19	+H	823.41106	823.41217	1.3	C42H62O16	Glycyrrhizic acid	METLIN ID 44285
30	18.79	+H	403.13874	403.13865	−0.2	C21H22O8	Nobiletin	METLIN ID 44436
31	20.28	+H	373.12818	373.12836	0.5	C20H20O7	Sinensetin	METLIN ID 49674