Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-κB Signaling Pathway

Figure 9

The effects of GSPE and BAY11-7082 on the expression of IKK, IκB, p50, and p65 protein ECA109 cells. (a) The inhibition of the IKK protein expression by GSPE (0–80 μg/mL) and BAY11-7082 (10 μmol/L). (b) The inhibition of IκB protein expression by GSPE (0–80 μg/mL) and BAY11-7082 (10 μmol/L). (c) The inhibition of p-IκB protein expression by GSPE (0–80 μg/mL) and BAY11-7082 (10 μmol/L). (d) The inhibition of p65 protein expression by GSPE (0–80 μg/mL) and BAY11-7082 (10 μmol/L). (e) The inhibition of p50 protein expression by GSPE (0–80 μg/mL) and BAY11-7082 (10 μmol/L). The mean ± SD of three groups of independent samples are shown in each column. compared with the GSPE 0, BAY11-7082–; compared with the GSPE 0, BAY11-7082+ group; compared with the BAY11-7082 group.

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