Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4^−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi

Figure 1

Morphological analysis of the heart of Balb/c WT and Balb/c IL-4^−/− mice infected and not infected with the Colombian strain of T. cruzi in the acute phase of experimental Chagas’ disease. (a) Density of amastigote nests in cardiac tissue of infected WT and IL-4^−/− mice. Bars represent the mean, and vertical lines represent the standard error. (b) Intensity of cardiac inflammatory infiltrate in infected WT and IL-4^−/− mice (, chi-square test). (c) Percentage of collagen fibers in cardiac tissue of infected and uninfected WT and IL-4^−/− mice. Bars represent the mean, and vertical lines represent the standard error. Histological sections of the WT and IL-4^−/−-infected mice heart. (d, g) HE-stained amastigote nests. (e) Mild inflammatory infiltrate. (h) Moderated inflammatory infiltrate. (f, i) Collagen fibers stained red by sirius red.

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