Sevoflurane Exacerbates Cognitive Impairment Induced by Aβ_1–40 in Rats through Initiating Neurotoxicity, Neuroinflammation, and Neuronal Apoptosis in Rat Hippocampus

Figure 2

Effects of sevoflurane on animal health. To verify whether inhalation anesthesia with sevoflurane was toxic to animals, the NS- and Aβ-treated rats inhaled 2.5% sevoflurane for 1–4 hours, and then MAP (a), heart beats (b), pH (c), PaCO₂ (d), PaO₂ (e), and HCO₃⁻ (f) were continuously monitored in the animals. There were no statistical significance in the above-stated parameters among 4 different time points in the NS + sevo group or Aβ + sevo group (all and in each group).

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