IL-33/IL-31 Axis: A Potential Inflammatory Pathway

Figure 2

Visual description of the IL-31 and IL-33 cascades leading to the activation of the genes and the proteins involved in the development of inflammatory disorders. IL: interleukin; OSMR: oncostatin-M-specific receptor beta; IL-31-RA: interleukin-31 receptor A; JAK: Janus kinase; STAT: signal transducers and activators of transcription; PI3: phosphoinositide-3-kinase; AKT: protein kinase B; MAPK: mitogen-activated protein kinase; AD: atopic dermatitis; ST2: soluble receptor; IL-1RAcP: IL-1R accessory protein; TIR: toll/interleukin-1 receptor; MyD88: myeloid differentiation primary response protein; IRAK: interleukin-1 receptor-associated kinase; IKB: I kappa B; NF-κB: nuclear factor- (NF-) κB; ERK: extracellular signal-regulated kinase; JNK: Jun N-terminal kinases; Th: T helper; CCL: chemokine (C-C motif) ligand; TNF: tumor necrosis factor.