Upregulation of Plasminogen Activator Inhibitor-1 in Irradiated Recipient Arteries and Veins from Free Tissue Transfer Reconstruction in Cancer Patients

Table 1

Demography of the cohorts. Seven patients participated in both the arterial and the venous groups (AV), 5 only in the arterial group (A), and 5 only in the venous group (V). (XRT = radiotherapy; Gy = gray; RFF = radial forearm flap; FIB = fibular flap; ALT = anterior lateral thigh; and DIEP = deep inferior epigastric perforator). Individual patient characteristics are listed in Supplementary Materials (available here).

Variable	Arterial group	Venous group	Total
Number ()	12 (7 + 5)	12 (7 + 5)	17 (7 + 5 + 5)
Male (AV + A or V)	8 (6 + 2)	9 (6 + 3)	11 (6 + 2 + 3)
Female (AV + A or V)	4 (1 + 3)	3 (1 + 2)	6 (1 + 3 + 2)
Median age (years) [range]	63 [30–77]	59 [30–77]	59 [30–77]
RFF	5	6	7
FIB	6	4	7
ALT	1	1	2
DIEP	0	1	1
Median XRT dose (Gy) [range]	64 [60.3–68]	64 [50–68]	64 [50–68]
Median after XRT (weeks) [range]	118 [5–650]	69 [5–450]	90 [5–650]
Mean after XRT (weeks) [range]	161 [5–650]	117 [5–450]	150 [5–650]
Current smoking () [%]	2 [17]	2 [17]	3 [18]
Cardiovascular disease () [%]	1 [8]	2 [17]	2 [12]
Hypertension	4 [33]	3 [25]	4 [24]