Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality

Figure 2

The ex vivo production of NETs in healthy controls and patients with sepsis and severe sepsis. (a) NETosis from 21 healthy controls, 39 patients with sepsis, and 60 patients with severe sepsis following stimulation with 25 nM PMA for 4 hours ex vivo. An ANOVA between all 3 groups showed a significant difference where , with representing the significant differences in a post hoc Tukey’s test. (b) NETosis from 21 healthy controls, 30 patients with sepsis, and 39 patients with severe sepsis on day 4 following stimulation with 25 nM PMA for 4 hours ex vivo. An ANOVA between all 3 groups showed a significant difference (), with representing significant differences in a post hoc Tukey’s test. On day 7, there are 21 sepsis patients and 29 severe sepsis patients. There was a significant difference between healthy controls and patients with severe sepsis.

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