Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model

Figure 4

Infiltration of inflammatory CD45⁺ cells was observed in the parenchyma of the spinal cord (SC), brain, and optic nerve (ON) in the vehicle-treated NMO rats. The red arrow in (f) indicates infiltrated leukocytes surrounding blood vessels as “perivascular cuffing.” The C + A treatment evidently alleviated this condition. Immunostaining of CD45 and counterstaining with hematoxylin; scale bar = 100 μm. Transverse sections through the brain (near the ventricle), lumbar spinal cord, and optic nerve. (m, n) C + A treatment attenuated CNS inflammation at 1 (m) and 8 (n) weeks pi, as shown by inflammation scoring. versus the vehicle-treated NMO rats.

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