High-Fat Diet and Alcohol Intake Promotes Inflammation and Impairs Skin Wound Healing in Wistar Rats

Table 1

Area (mm²) and wound contraction rate (WCR) (%) in all experimental groups at day 0 and after 7, 14, and 21 days of treatment. Values are mean ± SD.

		C1	C2	HF	AL	HF + AL
Day 0	Area	158.5 ± 26.5	153.3 ± 11.6	164.5 ± 13.6	163.3 ± 12.5	160.38 ± 12.6
	WCR	00.00 ± 00.00	00.00 ± 00.00	00.00 ± 00.00	00.00 ± 00.00	00.00 ± 00.00
Day 7	Area	76.8 ± 17.6	102.8 ± 31.6	113.1 ± 13.9	105.6 ± 8.2	115.4 ± 14.9
	WCR	50.51 ± 12.6	29.06 ± 11.7	39.77 ± 21.53	37.73 ± 13.1	31.9 ± 17.4
Day 14	Area	16.8 ± 9.1	15.9 ± 9.8	36.2 ± 11.9	30.3 ± 15.4	38.0 ± 12.3
	WCR	88.95 ± 5.5	89.16 ± 6.05	88.34 ± 7.96	81.30 ± 9.1	84.70 ± 9.29
Day 21	Area	3.2 ± 4.5	2.8 ± 1.7	9.1 ± 2.1	8.18 ± 4.6	10.4 ± 3.4
	WCR	96.73 ± 2.7	98.00 ± 1.2	94.06 ± 5.35	94.96 ± 2.61	94.38 ± 5.35

C1: control, water via gavage and standard chow diet; C2: control, water (no gavage) and standard chow diet; HF: water (no gavage) and high-fat diet (50%); AL: alcohol (40%) via gavage and standard chow diet; HF + AL: alcohol (40%) via gavage and high-fat diet. indicates statistical differences versus C1 and C2.