Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases

Table 4

Association between circulating chemerin levels and inflammatory marker and adipokine levels.

Clinical biochemical parameters		Unadjusted		Adjusted for age and sex			Adjusted for age, sex, and smoking
			value		value	Adjusted value		value	Adjusted value
Inflammatory markers	CRP (mg/L)	0.361	2.50 × 10^−19	0.349	5.26 × 10^−18	<0.001	0.339	5.92 × 10^−17	<0.001
	Fibrinogen (μmol/L)	0.165	6.22 × 10^−5	0.137	0.001	0.015	0.132	0.001	0.015
	SAA (μg/mL)	0.245	3.41 × 10^−9	0.233	2.05 × 10^−8	<0.001	0.232	2.65 × 10^−8	<0.001
	sE-Selectin (g/L)	0.134	0.001	0.146	4.69 × 10^−4	0.007	0.132	0.002	0.030
	sP-Selectin (ng/mL)	0.129	0.002	0.128	0.002	0.030	0.123	0.003	0.045
	sVCAM1 (g/L)	−0.028	0.498	−0.056	0.178	1.0	−0.059	0.159	1.0
	sICAM1 (g/L)	0.122	0.003	0.114	0.006	1.0	0.094	0.024	1.0
	MMP1 (pg/mL)	0.113	0.007	0.121	0.004	1.0	0.113	0.006	1.0
	sTNFRII (pg/mL)	0.141	0.001	0.123	0.003	0.045	0.119	0.004	1.0
	MMP2 (ng/mL)	−0.104	0.012	−0.13	0.002	0.030	−0.120	0.004	1.0
	MMP9 (mg/L)	0.063	0.136	0.08	0.058	1.0	0.061	0.149	1.0
	MCP1 (pg/mL)	0.045	0.282	0.043	0.303	1.0	0.040	0.335	1.0
	IL6 (pg/L)	0.139	0.001	0.137	0.001	0.015	0.131	0.002	0.030
Adipokines	Adiponectin (mg/L)	−0.128	0.002	−0.165	6.8 × 10^−5	0.001	−0.158	1.42 × 10^−4	0.002
	Leptin (g/L)	0.299	1.89 × 10^−13	0.36	4.21 × 10^−19	<0.001	0.359	4.95 × 10^−19	<0.001
	Resistin (ng/mL)	0.051	0.234	0.047	0.274	1.0	0.041	0.330	1.0
	Lipocalin 2 (ng/mL)	0.159	1.66 × 10^−4	0.165	9.2 × 10^−5	0.001	0.161	1.37 × 10^−4	0.002
	GDF15 (pg/mL)	0.167	5.20 × 10^−5	0.109	0.009	1.0	0.091	0.027	1.0

Data are presented as means ± SD or median (interquartile range) as appropriate. CRP: C-reactive protein; SAA: serum amyloid A; sE-selectin: soluble E-selectin; sP-selectin: soluble P-selectin; sVCAM1: soluble vascular cell adhesive molecule 1; sICAM1: soluble intercellular adhesive molecule 1; sTNFRII: soluble tumor necrosis factor-alpha receptor 2; MMP1: matrix metalloproteinase 1; MMP2: matrix metalloproteinase 2; MMP9: matrix metalloproteinase 9; MCP1: monocyte chemotactic protein 1; IL6: interleukin 6; GDF15: growth differentiation factor 15. For Bonferroni correction, .