Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases
Table 5
Association of RARRES2 gene polymorphisms with chemerin level.
SNP number
Gene
Position
MAF (MA)
MM
Mm
mm
β(SE)
value
MM
Mm + mm
value
rs7806429
RARRES2
3UTR
0.410 (C)
125.38 ± 47.13 (196)
130.60 ± 41.40 (285)
140.87 ± 43.42 (90)
0.027 (0.008)
0.001
125.38 ± 47.13 (196)
133.07 ± 42.07 (375)
0.009
rs4721
RARRES2
Intron
0.476 (C)
124.99 ± 48.87 (156)
130.18 ± 41.26 (289)
138.36 ± 43.02 (124)
0.023 (0.008)
0.002
124.99 ± 48.87 (156)
132.64 ± 41.91 (413)
0.019
rs17173608
RARRES2
Intron
0.067 (G)
130.72 ± 44.24 (499)
127.77 ± 41.41 (68)
151.39 ± 54.85 (4)
0.002 (0.015)
0.912
130.72 ± 44.24 (499)
129.08 ± 42.13 (72)
0.901
rs3735167
RARRES2
5UTR
0.284 (T)
125.11 ± 45.26 (292)
133.79 ± 47.77 (231)
147.16 ± 36.54 (46)
0.038 (0.008)
5.27 × 10−6
125.11 ± 45.26 (292)
136.16 ± 40.27 (277)
4.33 × 10−5
rs10244748
RARRES2
5UTR
0.214 (C)
130.06 ± 37.82 (351)
132.53 ± 53.33 (194)
121.26 ± 46.48 (23)
−0.013 (0.009)
0.174
130.06 ± 37.82 (351)
131.34 ± 52.67 (217)
0.353
rs10282458
RARRES2
5UTR
0.283 (A)
125.61 ± 45.79 (289)
133.59 ± 42.42 (236)
147.02 ± 35.37 (43)
0.038 (0.008)
1.08 × 10−5
125.61 ± 45.79 (289)
135.66 ± 41.64 (279)
8.91 × 10−5
value adjusted for age, sex, body mass index, and smoking, and antihypertensive, antidiabetic, and lipid-lowering drugs. MAF: minor allele frequency; MA: minor allele; MM: homozygosity of major allele; Mm: heterozygosity; mm: homozygosity of minor allele.
