IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney
IL-17 and IL-17 target gene expressions are increased in the obstructed kidney of WT mice. WT mice were subjected to UUO (–11). Mice were sacrificed at day 7 post-surgery, and renal transcript expressions of (a) Il17a, Il17f, Il17c, and Il17e, and (b) IL-17-responsive genes (Il6, Ccl20, Cxcl1, and Cxcl2) in the UUO and non-UUO kidneys were evaluated by qPCR. In the scattered plots, each dot represents individual mouse and error bars indicate . The data are pooled from three independent experiments. value ≤0.05 (), ≤0.001 (), and ≤0.0001 (). ns: not significant.
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