IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney

Figure 7

Activation of Bdkrb2 and Bdkrb1 which are key downstream mediators of IL-17-KKS axis-driven renal protection against TF. Groups of WT mice () were either treated with selective agonist for Bdkrb1 or Bdkrb2 or left untreated (NT). Mice were evaluated for fibrosis development over a period of 7 days post-UUO surgery by (a) Masson’s trichome staining and (b) measuring total collagen content in the UUO and non-UUO kidneys. Photomicrographs are representative of 2 independent experiments. Original magnification: 20x. In the scattered plots, each dot represents individual mouse and error bars indicate . The data are pooled from two independent experiments. value ≤0.05 () and ≤0.001 (). ns: not significant.

(a)

(b)