Mediators of Inflammation

Research Article

Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Table 2

Differences in clinical and laboratory parameters by metabolic health status: BMI < 25 kg/m².


	Metabolically healthy		Metabolically unhealthy		value
		Median (IQR)		Median (IQR)	value

HIV−
Age (years)	124	55 (50, 62)	9	59 (54, 62)	0.41
IL-6 (pg/mL)	115	1.1 (0.6, 1.8)	9	1.1 (1.0, 1.6)	0.55
hs-CRP (μg/mL)	118	0.8 (0.4, 1.3)	9	1.0 (0.3, 1.2)	0.95
sTNFRI (pg/mL)	118	1075 (914, 1317)	9	848 (699, 1319)	0.25
sTNFRII (pg/mL)	118	5496 (4737, 6595)	9	5904 (3912, 6065)	0.34
sCD163 (ng/mL)	113	511 (418, 674)	9	549 (323, 655)	0.51
sCD14 (ng/mL)	111	1341 (1126, 1549)	9	122 (1158, 1425)	0.42
Adiponectin (ng/mL)	117	9441 (6955, 13399)	9	3654 (3111, 5020)	0.001
Leptin (pg/mL)	117	2958 (1556, 4924)	9	3436 (3082, 3972)	0.24
Abdominal VAT area (cm²)	123	87 (54, 118)	9	145 (114, 165)	0.002
Thigh subcutaneous fat area (cm²)	124	35 (26, 44)	9	32 (26, 35)	0.42
HOMA-IR (mmol/L × μU/mL)	107	2.0 (2.0, 3.0)	9	3.0 (2.0, 4.0)	0.03

HIV+
Age (years)	164	53 (49, 59)	42	57 (52, 62)	0.02
IL-6 (pg/mL)	159	1.3 (0.8, 2.1)	40	1.9 (1.1, 2.3)	0.03
hs-CRP (μg/mL)	159	1.1 (0.5, 2.6)	40	1.6 (0.8, 2.9)	0.06
sTNFRI (pg/mL)	160	1151 (948, 1421)	41	1416 (1171, 1811)	<0.001
sTNFRII (pg/mL)	160	6302 (5307, 7531)	41	7126 (6343, 10,467)	0.001
sCD163 (ng/mL)	150	601 (451, 807)	37	699 (577, 893)	0.12
sCD14 (ng/mL)	151	1728 (1517, 2015)	35	1807 (1539, 2204)	0.18
Adiponectin (ng/mL)	158	8375 (4850, 12,397)	40	4392 (2375, 8370)	<0.001
Leptin (pg/mL)	158	2733 (1540, 5208)	40	3995 (1764, 7720)	0.07
Abdominal VAT area (cm²)	164	108 (62, 154)	41	182 (139, 217)	<0.001
Thigh subcutaneous fat area (cm²)	164	18 (7, 31)	41	10 (4, 18)	0.001
HOMA-IR (mmol/L × μU/mL)	135	3.0 (2.0, 3.0)	40	4.0 (3.0, 6.0)	<0.001

HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.