Mediators of Inflammation / 2018 / Article / Tab 3

Research Article

Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Table 3

Differences in clinical and laboratory parameters by metabolic health status: BMI > 30 kg/m2.

Metabolically healthyMetabolically unhealthy value
Median (IQR)Median (IQR)

HIV−
Age (years)3153 (45, 62)6056 (51, 62)0.1
IL-6 (pg/mL)301.4 (1.0, 1.8)532.0 (1.5, 3.0)0.02
hs-CRP (μg/mL)301.4 (0.9, 3.8)552.7 (0.9, 5.2)0.39
sTNFRI (pg/mL)301240 (1017, 1309)551275 (1056, 1485)0.45
sTNFRII (pg/mL)306120 (4976, 6961)556479 (5511, 7818)0.27
sCD163 (ng/mL)30597 (424, 705)52628 (503, 813)0.11
sCD14 (ng/mL)301250 (1078, 1433)531274 (1133, 1447)0.49
Adiponectin (ng/mL)306464 (4916, 7964)545025 (3862, 6657)0.02
Leptin (pg/mL)3013887 (10703, 21452)5418829 (12350, 28725)0.05
Abdominal VAT area (cm2)31190 (140, 263)60262 (202, 325)0.004
Thigh subcutaneous fat area (cm2)3110.5 (7.6, 17.4)6011.5 (9.4, 14.6)0.82
HOMA-IR (mmol/L × μU/mL)293.0 (2.0, 4.0)535.0 (4.0, 8.0)<0.001

HIV+
Age (years)2353 (47, 59)6252 (47, 57)0.53
IL-6 (pg/mL)231.6 (1.0, 2.3)581.8 (1.3, 2.5)0.27
hs-CRP (μg/mL)221.4 (0.8, 2.8)591.7 (0.9, 3.0)0.36
sTNFRI (pg/mL)231226 (1023, 1499)591150 (946, 1499)0.50
sTNFRII (pg/mL)235751 (5008, 7785)596271 (5334, 7684)0.36
sCD163 (ng/mL)23646 (513, 793)58686 (486, 835)0.76
sCD14 (ng/mL)231453 (1336, 1672)581495 (1240, 1771)0.73
Adiponectin (ng/mL)236167 (3876, 8089)604359 (3044, 5910)0.009
Leptin (pg/mL)2314262 (8409, 16957)6013318 (10965, 20808)0.64
Abdominal VAT area (cm2)23183 (134, 242)62267 (205, 352)0.001
Thigh subcutaneous fat area (cm2)2362 (41, 94)6244 (26, 74)0.09
HOMA-IR (mmol/L × μU/mL)223.0 (2.0, 4.0)586.0 (4.0, 10.0)<0.001

HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.

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