Mediators of Inflammation / 2018 / Article / Tab 4

Research Article

Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Table 4

Biomarkers concentrations by metabolic health status and HIV serostatus.

BiomarkersMetabolically healthyMetabolically unhealthy
HIV (−) ()HIV (−)HIV (+) ()HIV (+) valueHIV (−) ()HIV (−)HIV (+) ()HIV (+) value

BMI < 25 kg/m2
IL-6 (pg/mL)1151.1 (0.6–1.8)1591.3 (0.8–2.1)0.03491.1 (1–1.6)401.9 (1.1–2.3)0.121
hs-CRP (μg/mL)1180.8 (0.4–1.3)1591.1 (0.5–2.6)0.00191 (0.3–1.2)401.6 (0.8–2.9)0.054
sTNFRI (pg/mL)1181075 (914–1317)1601151 (948–1421)0.1469848 (699–1319)411416 (1171–1811)0.003
sTNFRII (pg/mL)1185496 (4737–6595)1606302 (5307–7531)0.00195904 (3912–6065)417126 (6343–10467)0.001
sCD 163 (ng/mL)113511 (418–674)150601 (451–807)0.0029549 (323–655)37699 (577–893)0.013
sCD 14 (ng/mL)1111341 (1126–1549)1511728 (1517–2015)<0.00191221 (1158–1425)351807 (1539–2204)<0.001
Adiponectin (ng/mL)1179441 (6955–13399)1588375 (4850–12397)0.02593654 (3111–5020)404392 (2375–8370)0.928
Leptin (pg/mL)1172958 (1556–4924)1582733 (1540–5208)0.97793436 (3082–3972)403995 (1764–7720)0.969
Abdominal VAT area (cm2)12387 (54–118)164108 (62–154)0.0069145 (114–165)41182 (139–217)0.024
Thigh subcutaneous fat area (cm2)12435 (26–44)16418 (7–31)<0.001932 (26–35)4110 (4–18)<0.001
HOMA-IR (mmol/L × μU/mL)1072 (2-3)1353 (2-3)<0.00193 (2–4)404 (3–6)0.056

BMI > 30 kg/m2
IL-6 (pg/mL)301.4 (1–1.8)231.6 (1–2.3)0.747532 (1.5–3)581.8 (1.3–2.5)0.277
hs-CRP (μg/mL)301.4 (0.9–3.8)221.4 (0.8–2.8)0.42552.7 (0.9–5.2)591.7 (0.9–3)0.179
sTNFRI (pg/mL)301240 (1017–1309)231226 (1023–1499)0.74551275 (1056–1485)591150 (946–1499)0.269
sTNFRII (pg/mL)306120 (4976–6961)235751 (5008–7785)0.964556479 (5511–7818)59530.816
sCD 163 (ng/mL)30597 (424–705)23646 (513–793)0.11652628 (503–813)58686 (486–835)0.484
sCD 14 (ng/mL)301250 (1078–1433)231453 (1336–1672)0.01531274 (1133–1447)581495 (1240–1771)0.002
Adiponectin (ng/mL)306464 (4916–7964)236167 (3876–8089)0.74545025 (3862–6657)604359 (3044–5910)0.135
Leptin (pg/mL)3013887 (10703–21452)2314262 (8409–16957)0.665418829 (12350–28725)6013318 (10965–20808)0.028
Abdomen visceral fat area (cm2)31190 (140–263)23183 (134–242)0.76660262 (202–325)62267 (205–352)0.456
Thigh subcutaneous fat area (cm2)3183 (69–123)2362 (41–94)0.0046082 (61–101)6244 (26–74)<0.001
HOMA-IR (mmol/L × μU/mL)293 (2–4)223 (2–4)0.718535 (4–8)586 (4–10)0.422

Median (interquartile range); HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.

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