Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

Table 5

Adjusted prevalence ratio for metabolic health among HIV+ men stratified by BMI categories per log biomarker increase.

Biomarkers	BMI < 25; PR (95% CI)	value	BMI > 30; PR (95% CI)	value
IL-6	0.92 (0.84, 1.01)	0.07	0.67 (0.36, 1.27)	0.222
hs-CRP	0.92 (0.87, 0.98)	0.01	0.78 (0.52, 1.16)	0.222
sTNFRI	0.73 (0.61, 0.87)	<0.001	1.25 (0.46, 3.42)	0.662
sTNFRII	0.68 (0.54, 0.85)	0.001	0.48 (0.13, 1.81)	0.28
sCD163	0.92 (0.77, 1.1)	0.35	1.05 (0.42, 2.62)	0.916
sCD14	0.89 (0.79, 1.01)	0.07	1.47 (1, 2.17)	0.052
Adiponectin	1.27 (1.12, 1.43)	<0.001	2.36 (1.35, 4.13)	0.003
Leptin	0.93 (0.84, 1.03)	0.15	0.87 (0.58, 1.3)	0.498
HOMA-IR	0.69 (0.55, 0.86)	<0.001	0.22 (0.08, 0.59)	0.003

BMI: body mass index; CI: confidence interval; IL-6: interleukin-6; hs-CRP: high-sensitivity C-reactive protein; sTNFRI-II: soluble tumor necrosis factor receptor I-II; sCD163: soluble CD163; sCD14: soluble CD14; HOMA-IR: homeostatic model assessment of insulin resistance.