Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

Figure 11

Protein expressions of apoptotic, fibrotic, and mitochondrial damage biomarkers in lung parenchyma by day 5 after ARDS induction. (a) Protein expression of cleaved caspase 3 (c-Casp 3), versus other groups with different symbols (†, ‡, §, ¶), . (b) Protein expression of cleaved poly(ADP-ribose) polymerase (c-PARP), versus other groups with different symbols (†, ‡, §, ¶), . (c) Protein expression of phosphorylated- (p-) Smad3, versus other groups with different symbols (†, ‡, §, ¶), . (d) Protein expression of transforming growth factor- (TGF-) β, versus other groups with different symbols (†, ‡, §, ¶), . (e) Protein expression of cytosolic cytochrome c (cyt-Cyto c), versus other groups with different symbols (†, ‡, §, ¶), . (f) Protein expression of mitochondrial cytochrome c (mit-Cyto c), versus other groups with different symbols (†, ‡, §, ¶), . All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (, †, ‡, §, ¶) indicate significance (at 0.05 level). SC = sham control; ARDS = acute respiratory distress syndrome; Mito = mitochondria; SW = shock wave.

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