Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

Figure 4

Effect of Sema3A on gene expression of inflammatory mediators under excessive mechanical stress. ATDC5 cells treated with various concentrations of Sema3A were subjected to excessive CTS for 3 h. Gene expression of IL-1β, TNF-α, COX-2, MMP-3, and MMP-13 was measured by qPCR (a–e). Data are expressed as mean ± SD, . , compared to the group with CTS but without Sema3A.

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