Activation of GABA_B Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn

Figure 2

Neuropathic pain behavior in the control, diabetic neuropathic pain (DNP), DNP + LPS-RS (TLR4 antagonist), DNP + MIP (Myd88 antagonist), and DNP + SN50 (NF-κB inhibitor) groups at 0, 1, 2, and 3 days after intrathecal administration. (a, c, e). The mechanical paw withdrawal threshold (PWT) (g). (b, d, f). The paw withdrawal thermal latency (PWTL) (s). Bar graphs represent mean ± SEM. , compared with the DNP group ().

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