Research Article

Activation of GABAB Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn

Table 2

Comparison of thermal paw withdrawal latency (in seconds, , mean ± SE) in rats.

GroupBaseline7 days14 days21 days

Control15.6 ± 2.8115.8 ± 2.915.7 ± 2.715.9 ± 2.6
DNP15.8 ± 3.5111.8 ± 3.58.4 ± 2.5,7.8 ± 1.7,
LPS-RS + DNP16.9 ± 3.3112.6 ± 3.97.9 ± 1.9,7.2 ± 2.0,
SN50 + DNP16.2 ± 2.9113.5 ± 4.08.2 ± 2.1,7.5 ± 2.1,
MIP + DNP15.9 ± 2.6112.9 ± 3.87.7 ± 1.6,7.7 ± 2.3,
Baclofen + DNP16.5 ± 3.8113.3 ± 4.48.1 ± 2.2,7.9 ± 1.6,
Saclofen + DNP15.5 ± 2.7112.7 ± 3.67.5 ± 1.8,7.2 ± 2.2,

Compared with baseline values, . Compared with the control group, .