Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice

<div>Alloxan diabetes suppressed cytokine production in the lung tissue of sensitized OVA-challenged mice. IL-5 (a), CCL-11/eotaxin (b), and CCL-3/MIP-1<i>α</i> (c) production in lung tissue from nondiabetic or diabetic mice challenged with saline or ovalbumin (OVA) was analyzed by ELISA. The analysis proceeded 24 h after the last OVA challenge. Each value indicates the mean ± SEM from six animals per group. <svg height="11.4337pt" id="M18" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.7967 68.3436 11.4337" width="68.3436pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z" id="g54-36"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.56,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z" id="g54-36"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.12,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z" id="g54-36"></path></g><g transform="matrix(.013,0,0,-0.013,17.241,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 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Mediators of Inflammation

Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice

Figure 4