Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model

Figure 5

Resveratrol reduces intestinal ischemia-reperfusion injury by inhibiting mast cell-related NLRP3 inflammasome activation. Under intestinal ischemia-reperfusion conditions, mast cells are activated and degranulated. Cytokine TNF-α was released following mast cells activation, resulting in NLRP3-related inflammasome activation and subsequent IL-1β generation. Amount of proinflammatory cytokines produced and released from intestinal mucosa epithelial cells. Resveratrol pretreatment prevented the mast cells from degranulation via stabilizing mast cell membrane, which inhibited intestinal mucosa epithelial cell NLRP3-related inflammasome activation.