Research Article
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
Table 1
Genotype distribution of IL-6 and IL-10 polymorphisms in DS and control groups.
| | Models | Genotype | Control ( (%)) | DS ( (%)) | OR (95% CI) | value | Genotype | Control ( (%)) | DS ( (%)) | OR (95% CI) | value |
| | | IL-6 -597G>A | IL-10 -1082A>G | | Codominant | GG | 107 (53.5) | 122 (61) | 1.00 | 0.22 | AA | 104 (52) | 95 (47.5) | 1.00 | 0.44 | | GA | 79 (39.5) | 70 (35) | 1.28 (0.84–1.93) | AG | 63 (31.5) | 75 (37.5) | 0.76 (0.49–1.18) | | AA | 14 (7) | 08 (4) | 1.99 (0.80–4.92) | GG | 33 (16.5) | 30 (15) | 1.01 (0.57–1.78) | | Dominant | GG | 107 (53.5) | 122 (61) | 1.00 | 0.14 | AA | 104 (52) | 95 (47.5) | 1.00 | 0.36 | | GA/AA | 93 (46.5) | 78 (39) | 1.35 (0.91–2.01) | AG/GG | 96 (48) | 105 (52.5) | 0.83 (0.56–1.23) | | Recessive | GG/GA | 186 (93) | 192 (96) | 1.00 | 0.19 | AA/AG | 167 (83.5) | 170 (85) | 1.00 | 0.67 | | AA | 14 (7) | 08 (4) | 1.80 (0.74–4.40) | GG | 33 (16.5) | 30 (15) | 1.12 (0.66–1.93) |
| | | IL-6 -174G>C | IL-10 -592C>A | | Codominant | GG | 108 (54) | 120 (60) | 1.00 | 0.41 | CC | 98 (49) | 91 (45.5) | 1.00 | 0.70 | | GC | 80 (40) | 72 (36) | 1.22 (0.81–1.85) | CA | 78 (39) | 86 (43) | 0.84 (0.55–1.27) | | CC | 12 (6) | 08 (4) | 1.66 (0.65–4.21) | AA | 24 (12) | 23 (11.5) | 0.96 (0.51–1.83) | | Dominant | GG | 108 (54) | 120 (60) | 1.00 | 0.24 | CC | 98 (49) | 91 (45.5) | 1.00 | 0.47 | | GC/CC | 92 (46) | 80 (40) | 1.27 (0.85–1.89) | CA/AA | 102 (51) | 109 (54.5) | 0.86 (0.58–1.28) | | Recessive | GG/GC | 188 (94) | 192 (96) | 1.00 | 0.36 | CC/CA | 176 (88) | 177 (88.5) | 1.00 | 0.88 | | CC | 12 (6) | 08 (4) | 1.53 (0.61–3.82) | AA | 24 (12) | 23 (11.5) | 1.05 (0.57–1.93) |
| | | IL-06 -572G>C | IL-10 -819C>T | | Codominant | GG | 155 (77.5) | 156 (78) | 1.00 | 0.37 | CC | 84 (42) | 83 (41.5) | 1.00 | 0.13 | | GC | 41 (20.5) | 43 (21.5) | 0.97 (0.6–1.57) | CT | 80 (40) | 94 (47) | 0.84 (0.55–1.28) | | CC | 04 (2) | 01 (0.5) | 4.07 (0.45–36.78) | TT | 36 (18) | 23 (11.5) | 1.54 (0.84–2.82) | | Dominant | GG | 155 (77.5) | 156 (78) | 1.00 | 0.88 | CC | 84 (42) | 83 (41.5) | 1.00 | 0.91 | | GC/CC | 45 (22.5) | 44 (22) | 1.04 (0.65–1.66) | CT/TT | 116 (58) | 117 (58.5) | 0.98 (0.66–1.45) | | Recessive | GG/GC | 196 (98) | 199 (99.5) | 1.00 | 0.16 | CC/CT | 164 (82) | 177 (88.5) | 1.00 | 0.07 | | CC | 04 (2) | 01 (0.5) | 4.10 (0.45–36.96) | TT | 36 (18) | 23 (11.5) | 1.69 (0.96–2.97) |
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DS: Down syndrome; OR: odds ratio; CI: confidence interval.
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